It may be most convenient to respond to Dr Andreae’s points in turn. Unless the claim that a child should determine its own genetic characteristics before it is conceived or born is intended to be flippant, it is logically incoherent. Conception is a decision that only a prospective parent can make. The editorial argument is that denial of choice of sex contributes to preventable maternal mortality and morbidity, particularly in developing countries. ….

The title of this article might quite well be given the more hackneyed form, Has Kant answered Hume? Much of the discussion pertains to this latter question, but as the aim is also to emphasize some points concerned with Kant himself a deviation in title may be permissible.

Le système des sciences ne peut être globale qu'à la condition d'incorporer non seulement les sciences fondamentales mais aussi les sciences techniques et appliquées. Pour expliquer cette incorporation nous proposons de tenir compte non Seulement du moment objectif mais aussi du moment subject. En répondant aux questions: qu'est-ce qu'on étudie?, comment on étudie? pour quel but on étudie? nous découvrons l'accroissement de la proportion du moment subjectif ce qui permets à dresser un système globale des sciences.

The problem we are discussing has many aspects.

The discovery of spectrum analysis occupies an important place on the long and thorny path of the advance of human knowledge toward the atoms, the stars, and the mastery of their laws. This great discovery was made one hundred years ago . The decisive role in this achievement belongs by right to two outstanding German scientists, Robert Bunsen and Gustav Kirchhoff. This discovery simultaneously opened the path into the atomic world, making it possible to judge the internal structure of atoms (...) from their optical properties, and into the world of heavenly bodies, the chemical composition of whose substances was first determined by means of spectrum analysis. All this led to an unprecedented expansion of the field of scientific knowledge both in the direction of the investigation of microscopic objects in nature and in that of the study of macro-objects. But the most remarkable thing was that in their development both these trends in research proved to be interrelated. The penetration of science into the field of the macro-cosmos was a direct consequence of its more profound penetration into the field of the micro-cosmos. In a word, this was one of the boldest of scientific achievements, one that enabled human reason to penetrate into the depths of the substance of the earth and the cosmos, to know its properties, its composition, and its laws. (shrink)

The question of contacts between philosophers and historians of natural science, of mutual assistance and collaboration in their work, is an exceptionally important one from both the theoretical and practical points of view. This constitutes an organic component of the overall task, posed by Lenin, of strengthening the alliance between the leading natural scientists and Marxist philosophers. Here a businesslike approach is particularly needed. Lenin's behests lay in two directions. First, they have to do with the treatment of problems in (...) the history of knowledge from the standpoint of philosophy, and, second, they deal with the treatment of problems of dialectical philosophy on the basis of generalization from the data of the history of natural science. The two problems are interrelated, but they can also be considered as relatively independent. The common dialectical foundation of both sets of problems is the idea of the unity, the interconnection, of the historical and the logical. What are the behests of Lenin, and how are they being carried out? (shrink)

The subject of the present paper is the central conception of a philosophy that has been particularly dominant and influential, and the following remarks are prompted because of difficulties experienced in the attempt to understand that philosophy. The aim of the paper is to point out what seems to be a serious defect in that type of philosophy; but it is even more its aim to emphasize the danger into which philosophy in all its forms may easily fall, and against (...) which it must exercise precautions. (shrink)

Philosophers and natural scientists are both familiar with the fact that, nearly a century ago, Engels undertook to synthesize the findings of natural science in his day from the standpoint of materialist dialectics. But few know the price Engels paid, how many times the work approached completion but was, for various reasons, postponed again and again until his death. In his mind, what place was his Dialectics of Nature to have occupied in the overall system of Marxist theory? This is (...) the question to which I devote the present article. But before offering an answer, it is necessary to trace, albeit briefly, the history of this book — how it was conceived by Engels, how work on it progressed, how it was broken off, and how the incomplete manuscript came down to us. (shrink)

The question of a new journal and the philosophical debate of 1947 In 1922-43 Soviet philosophers had their own journal titled Pod znamenem marksizma [Under the Banner of Marxism]. It came into being in early 1922 and its third issue contained Lenin's programmatic article "On the Significance of Militant Materialism" [O znachenii voinstvuiushchego materializma]. This journal published many good combative articles in its twenty years. But during the War it fell ill and in mid-1943 ceased to exist. It was not (...) discontinued. No, it simply lacked the strength to appear. Thereafter, we Soviet philosophers did not have our own journal for several years. The lack was felt especially keenly after the end of the Great Patriotic War when philosophical studies developed quickly in our country. A wide discussion of philosophical questions, especially contentious, controversial questions—and there were quite a few of them—became necessary but there was no forum for discussing them. This was also true of the critical analysis of the philosophical literature that was coming out: a rare review appeared from time to time in the existing journals, but it was clearly inadequate and, most importantly, it did not give a comprehensive evaluation of the merits and shortcomings of the published philosophical work. It seemed to us then that an unhealthy situation such as the one involving G. F. Aleksandrov's book The History of Western European Philosophy [Istoriia zapadnoevropeiskoi filosofii], which was not evaluated on its merits and, despite its serious flaws, was praised by admirers of the author's talent, could only arise in the absence of a philosophical journal. Had there been a journal, it could have helped to prevent such stuffy situations from arising in certain sections of the philosophical front. Obviously, this opinion was quite naive: at the time many of us did not understand that if Aleksandrov had had "his" man on the journal, no criticism of his book would have been permitted. We realized this later. (shrink)

The question of the unity of scientific knowledge, including that of the unity of the natural sciences and the humanities , occupies an important place in the writings of Marx. As a consistent materialist, Marx demonstrated that the connection among the sciences was based on an objective connection among the phenomena of nature and society. This outlook provides the key to discovering the unity of the sciences in our own day. Let us see how Marx posed that question, and how (...) it stands today. (shrink)

There can be no doubt that the process of differentiation of the sciences today is going forward with rising intensity. This process is expressed in two ways: in the appearance of new sciences and disciplines outside those already existing, and as the further subdivision of existing sciences into narrower and more fragmented disciplinary branches.

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

The Genetic Information Nondiscrimination Act of 2008 prohibits most forms of discrimination on the basis of genetic information in health insurance and employment. The findings cited as justification for the act, the almost universal political support for it, and much of the scholarly literature about genetic discrimination, all betray a confusion about what is really at issue. They imply that genetic discrimination is wrong mainly because of genetic exceptionalism: because some special feature of genetic information makes discrimination on the basis (...) thereof wrong. I suggest, to the contrary, that the best arguments against genetic discrimination assume that health care is an entitlement . I do this by examining two different exceptionalist arguments for genetic nondiscrimination, showing that they do not furnish good reasons for prohibiting genetic discrimination unless one supposes that health care is an entitlement. (shrink)

THE question which I am to raise for discussion is one which has long been debated by philosophers, and consequently I consider it doubtful whether anything very new can be said on the matter. But it may be profitable to review once more the present position of the controversy and to have in mind the reasons which at present make the question of interest and of importance.

In the UK, over 70% of AIDS, including new cases, is located in a few Districts in central London where the distribution of previously occurring and new cases is essentially confined to the original risk groups of homosexual/bisexual men, drug addicts of both sexes, and some of their sexual partners and consorts. But control policy is still based on the assumption that HIV has already spread from persons in these risk groups into the general population, and that it will spread (...) hereafter at an increased rate because of heterosexual transmission to cause a widespread epidemic of AIDS.The basis and implications of this policy were investigated in the South East region adjacent to London, Analysis of demographic and epidemiological data shows that, with one exception, there is very little extension of AIDS from affected Districts in London to the surrounding region or even to the suburban fringe. Where AIDS is prevalent, as in this exception, the distribution follows the same, original pattern which relates essentially to risks arising from life-styles. There is no significant association between the prevalence or spread of AIDS and conventional markers of deprivation, economic and social disadvantage.Allocations of personnel, services and expenditure, assessed from returns required under the AIDS Control Act of 1987 and official registration data, continue to follow the original policy assumptions. They are therefore unrelated to the numbers of existing and new cases, disproportionate and unrealistic. Claims that this widespread excess of effort is justified by the fact that AIDS has not spread to the general population are falsified by the continuation of cases almost exclusively in risk groups. There is nothing in the data required under the Act or in registrations in this main locus of AIDS in the UK to suggest any change in this or to justify continuation of current expenditure and redundant activities.There is no evidence in these data that ethnic variations in the resident populations of Districts are associated with variations in the prevalence of AIDS. However, the larger figures available in some of the national data do indicate a disproportionate increase in some minority ethnic groups. Further detail about risks factors in these groups are required and, meanwhile, effort and expenditure should be re-orientated toward treatment, contact tracing and other public health measures for more effective containment of the continuing spread of AIDS in all the high risk groups. (shrink)

The study of the problem of religious relations is of particular interest, since upon the annexation to Russia, during the years 1794-1796, and in some places until 1798, the almost complete elimination of the Uniate Church in Right-Bank Ukraine took place. This issue has been covered extensively in pre-revolutionary historiography, including at the local level. Thus, the history of the existence and liquidation of the Uniate Church in Podillya became the leading topic of research of the "Podolsky Diocesan Historical and (...) Statistical Committee". Another printed organ, where the church-historical information about Podolsk parishes, collected by priests, became Podilskie Eparchial Gazettes. The main idea behind the content of these studies was that Podillya was considered as originally Russian possession, and Orthodoxy was the only possible denomination of the land. (shrink)

The Acarnanian chrēsmologos Amphilytos spoke the verses to Peisistratos just before the battle of Pallene in 546 b.c. They contain a prediction of imminent victory for Peisistratos and total defeat for the Athenians. The Athenians will be routed and deprived of political self-determination, while the victory will restore to Peisistratos the tyranny from which he was twice forced, ‘rooting’ it once for all. Of course, all of this appears quite evident from the narrative. But as the verses form part of (...) Herodotos' account of Peisistratos' ascent to power they amount to much more, for they constitute penultimate proof of Peisistratos' irresistibility , a recurrent theme in Herodotos' logos, but one which was undoubtedly encouraged by his Athenian sources as a means of explaining how the Athenians were forced to yield the tyranny. Indeed, the theme of irresistibility helps to excuse the Athenians for being overcome; as much of the logos, which is historically quite vague, it is a reaction to fact, not factual itself. (shrink)

We know that the Philosophical Notebooks do not constitute a finished work, but are working digests done by Lenin, not for publication but only for himself, and as a basis for further work on questions of dialectics. This circumstance must always be remembered when one turns to the Philosophical Notebooks. Here are recorded and collected Lenin's remarkable thoughts as they developed upon reading the works of Hegel and other philosophers as well as certain natural scientists, and Lenin's exceedingly valuable plans (...) and notions pertaining to further work on theoretical problems of the materialist dialectic. But, at the same time, the Philosophical Notebooks contain numerous passages copied by Lenin as he did the digests of the philosophical works he read. Moreover, it is sometimes difficult to say for what purpose and toward what end Lenin did this copying: was it in order subsequently to adduce these extracts and quotations in support of his own views and postulates; was it for purposes of criticism — to demonstrate that the propositions of Marxist dialectics were incompatible with them; or was it merely as the roughest kind of material for work he would subsequently do? Many of the copied extracts in the Philosophical Notebooks are accompanied by Lenin's critical remarks, negative and positive, in brief analyses and rather extensive commentaries. But some of them remained open questions for Lenin himself. In such an instance he noted for his own information that it would be necessary to return again to the proposition he had copied, because it was something that he did not fully understand: it seemed to him that at the given point Hegel wished to say this or that; but perhaps that is not the case. (shrink)